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March 26 , 2017

Clinical Trial

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Overview

The deadly hantavirus has killed hundreds of Native Americans, so when a reputable pharmaceutical company claims to have developed a vaccine against the deadly disease, it should be good news. But when ImmuVac asks Dr. Isabel McLain to conduct a clinical trial of the vaccine on the Blackfeet reservation in Browning, Montana, the proposal gets a distinctly mixed response from both her and the suspicious Blackfeet. Is the new drug truly safe, or are the Blackfeet being used as human guinea pigs?

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Clinical Trial Design

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role…

Indian activist Monty Four Bear fears the worst, but Dr. McLain stakes her reputation on the trial's safety. Having taken over the poorly-funded reservation clinic after the catastrophic failure of her marriage, Isabel has fought a long, hard struggle to gain the trust of the wary Blackfeet residents of the reservation. She knows she risks everything she's accomplished by endorsing ImmuVac's clinical trial, but she's willing to take that chance if it means developing a weapon against the hantavirus.

But when corporate greed makes for questionable science, whom can Isabel truly trust with her life and her career – and the lives of the Blackfeet?




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